Targeting CLEC12B Unleashes NK Cells for Enhanced Cancer Immunotherapy
Peng Sun, Xiaoyu Xu, Bian Hu, Huidi Chen, Hanyang Liu, Qingping Tao, Asad Khan, Sohail Khan, Björn Nashan, Cheng Sun
The complete record.
The full body of work from the laboratory — 41 peer-reviewed publications spanning spatial immunology, NK-cell biology, and cancer immunotherapy. Corresponding-author names are shown in bold.
2026
SAMSN1 Restrains NK Cell-Mediated Anti-Tumor Immunity in Hepatocellular Carcinoma
Ruifeng Wang, Huidi Chen, Bian Hu, Hanyan Liu, Qiang Li, Guojing Yao, Fuling Li, Peng Sun, Tianli Dai, Jiabei Wang, Björn Nashan, Cheng Sun
Metabolic Reinvigoration of NK Cells by IL-21 Enhances Immunotherapy Against MHC-I-Deficient Solid Tumors
Yi Wang, Chao Huang, Guoxin Cai, Massimo Andreatta, Armand Kurum, Yang Zhao, Bing Feng, Min Gao, Santiago J. Carmona, Zhan Zhou, Cheng Sun, Yugang Guo, Li Tang
2025
Spatial Immune Scoring System Predicts Hepatocellular Carcinoma Recurrence
Gengjie Jia, Peiqi He, Tianli Dai, Denise Goh, Jiabei Wang, Felicia Wee, Fuling Li, Shuxia Hao, Yao Liu, Qingping Tao, Wei Wang, Ahitsham Umar, Björn Nashan, Yongchang Zhang, Chen Ding, Joe Yeong, Lianxin Liu, Cheng Sun
Asia's Emergence in Cancer Immunotherapy: Challenges and Opportunities
Yan Li, Joe Yeong, Bernard A. Fox, Cheng Sun
2024
Proteomic Characterization Identifies Clinically Relevant Subgroups of Gastrointestinal Stromal Tumors
Mingjun Sun, Yexin Tong, Wei Yuan, Yunzhi Wang, et al., Cheng Sun, Kuntang Shen, Fuchu He, Yingyong Hou, Chen Ding
A Bispecific Antibody Targeting the Ig Domains of Siglec-E Displays Enhanced Antitumor Effects
View paper →2023
Systematic Characterization of Chromodomain Proteins Reveals an H3K9me1/2 Reader Regulating Aging in C. elegans
Xinhao Hou, Mingjing Xu, Chengming Zhu, Jianing Gao, Meili Li, Xiangyang Chen, Cheng Sun, Björn Nashan, Jianye Zang, Ying Zhou, Shouhong Guang, Xuezhu Feng
Regulatory Mucosa-Associated Invariant T Cells Controlled by β1 Adrenergic Receptor Signaling Contribute to Hepatocellular Carcinoma Progression
Sicheng Fu, Muziying Liu, Chenwen Zhu, Huimin Zhang, Changfeng Zhao, Yaping Xie, et al., Cheng Sun, Zhigang Tian, Hua Wang, Li Bai
Influence of Immunosuppressive Drugs on Natural Killer Cells in Therapeutic Drug Exposure in Liver Transplantation
Rongrong Qin, Jiwei Qin, Xuefeng Li, Zhijun Xu, Peiqi He, Xiaodong Yuan, Cheng Sun, Björn Nashan
2022
Panoramic Comparison Between NK Cells in Healthy and Cancerous Liver Through Single-Cell RNA Sequencing
Huan Liu, Ronghua Zhao, Rongrong Qin, Haoyu Sun, Qiang Huang, Lianxin Liu, Zhigang Tian, Björn Nashan, Cheng Sun, Rui Sun
Postmortem High-Dimensional Immune Profiling of Severe COVID-19 Patients Reveals Distinct Patterns of Immunosuppression and Immunoactivation
Haibo Wu, Peiqi He, Yong Ren, Shiqi Xiao, Wei Wang, Shuyang Zhang, Jiwei Qin, Björn Nashan, Cheng Sun
A Review of Spatial Profiling Technologies for Characterizing the Tumor Microenvironment in Immuno-Oncology
Bian Hu, Muhammad Sajid, Rong Lv, Lianxin Liu, Cheng Sun
The Dynamic Role of NK Cells in Liver Cancers: Role in HCC and HBV-Associated HCC and Its Therapeutic Implications
Muhammad Sajid, Lianxin Liu, Cheng Sun
The SNAPc Complex Mediates Starvation-Induced Trans-Splicing in Caenorhabditis elegans
Xinhao Hou, Chengming Zhu, Mingjing Xu, Xiangyang Chen, Cheng Sun, Björn Nashan, Shouhong Guang, Xuezhu Feng
2021
Innate Lymphoid Cells and Cancer: Role in Tumor Progression and Inhibition
Haoyu Sun, Jiabei Xu, Qiang Huang, Mei Huang, Kang Li, Kun Qu, Hua Wen, Rui Lin, Xiaodong Yuan, Faqiang Rasul, Björn Nashan, Cheng Sun
Blockade of Checkpoint Receptor PVRIG Unleashes Anti-Tumor Immunity of NK Cells in Murine and Human Solid Tumors
Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment
2020
Establishment and Preclinical Therapy of a Patient-Derived Hepatocellular Carcinoma Xenograft Model
Yuwei Wu, Jinyu Wang, Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun, Cheng Sun
Myeloid Signature Reveals Immune Contexture and Predicts the Prognosis of Hepatocellular Carcinoma
2019
Human CD96 Correlates to NK Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma
Haoyu Sun, Qiang Huang, Mei Huang, Hua Wen, Rui Lin, Minghui Zheng, Kun Qu, Kang Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun
Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
Haoyu Sun, Lianxin Liu, Qiang Huang, Huan Liu, Mei Huang, Jiabei Wang, Hua Wen, Rui Lin, Kun Qu, Kang Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun
The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy
Haoyu Sun, Cheng Sun
CD4+ T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model
Tingxin Wu, Fuling Li, Yongyan Chen, Haiming Wei, Zhigang Tian, Cheng Sun, Rui Sun
Breakdown of Adaptive Immunotolerance Induces Hepatocellular Carcinoma in HBsAg-tg Mice
Liang Zong, Hui Peng, Cheng Sun, Fuling Li, Minghui Zheng, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian
Tissue-Resident Lymphocytes: From Adaptive to Innate Immunity
Haoyu Sun, Cheng Sun, Weihua Xiao, Rui Sun
Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model
Chuanshan Zhang, Rui Lin, Zhide Li, Shanshan Yang, Xiaojuan Bi, et al., Cheng Sun, Dominique A. Vuitton, Zhigang Tian, Hao Wen
CD8+ T Cells Promote Maturation of Liver-Resident NK Cells Through the CD70-CD27 Axis
Li Bai, Hui Peng, Xiaodong Hao, Lu Tang, Cheng Sun, Minghui Zheng, Fuming Liu, Zhexiong Lian, Haiming Wei, Rui Sun, Zhigang Tian
2018
Reduced CD160 Expression Contributes to Impaired NK-Cell Function and Poor Clinical Outcomes in Patients with HCC
Minghui Zheng, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun
Oncofetal Gene SALL4 Reactivation by Hepatitis B Virus Counteracts miR-200c in PD-L1-Induced T Cell Exhaustion
Cheng Sun, Ping Lan, Qiuju Han, Mei Huang, Zhen Zhang, Guangyu Xu, Jie Song, Jiabei Wang, Haiming Wei, Jian Zhang, Rui Sun, Cheng Zhang, Zhigang Tian
2017
High NKG2A Expression Contributes to NK Cell Exhaustion and Predicts a Poor Prognosis of Patients with Liver Cancer
Cheng Sun, Jiabei Xu, Qiang Huang, Mei Huang, Hua Wen, Cheng Zhang, Jiabei Wang, Jie Song, Minghui Zheng, Haoyu Sun, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian
Association of Decreased Expression of the Macrophage Scavenger Receptor MARCO with Tumor Progression and Poor Prognosis in Human Hepatocellular Carcinoma
Haoyu Sun, Jie Song, Chuanhui Weng, Jiabei Xu, Mei Huang, Qiang Huang, Rui Sun, Weihua Xiao, Cheng Sun
Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances
Guowei Yan, Xiang Wang, Cheng Sun, Xiaodong Zheng, Haiming Wei, Zhigang Tian, Rui Sun
T-Cell Tolerance and Exhaustion in the Clearance of Echinococcus multilocularis: Role of Inoculum Size in a Quantitative Hepatic Experimental Model
Chuanshan Zhang, Ying Shao, Shanshan Yang, Xiaojuan Bi, Liang Li, Hui Wang, Ning Yang, Zhide Li, Cheng Sun, Dominique A. Vuitton, Rui Lin, Hao Wen
2016
CD200R, a Co-inhibitory Receptor on Immune Cells, Predicts the Prognosis of Human Hepatocellular Carcinoma
Haoyu Sun, Jiabei Xu, Mei Huang, Qiang Huang, Rui Sun, Weihua Xiao, Cheng Sun
2015
NK Cell Receptor Imbalance and NK Cell Dysfunction in HBV Infection and Hepatocellular Carcinoma
Cheng Sun, Haoyu Sun, Cheng Zhang, Zhigang Tian
The Predictive Value of Centre Tumour CD8+ T Cells in Patients with Hepatocellular Carcinoma: Comparison with Immunoscore
Cheng Sun, Jiabei Xu, Jie Song, Chang Liu, Jiabei Wang, Chuanhui Weng, Haoyu Sun, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian
Natural Killer Cell Dysfunction in Hepatocellular Carcinoma and NK Cell-Based Immunotherapy
Cheng Sun, Haoyu Sun, Weihua Xiao, Cheng Zhang, Zhigang Tian
2014
Expression Regulation of Co-inhibitory Molecules on Human Natural Killer Cells in Response to Cytokine Stimulations
Haoyu Sun, Cheng Sun, Weihua Xiao
2013
NK Cells in Immunotolerant Organs
Haoyu Sun, Cheng Sun, Zhigang Tian, Weihua Xiao
2012
TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence
Cheng Sun, Binqing Fu, Yongyan Gao, Xiaohu Liao, Rui Sun, Zhigang Tian, Haiming Wei